The knee is the most-studied joint for PRP — and the evidence is genuinely encouraging for mild to moderate arthritis.
"Knee pain" describes a location, not a diagnosis, and PRP is useful for some causes and useless for others. Sorting that out is the first job.
Examination and, where appropriate, imaging determine which of these applies. Treating the wrong one is the most common reason injections disappoint.
The knee is where PRP has been most extensively studied, and the picture is reasonably positive.
For mild to moderate knee osteoarthritis, multiple randomized trials and pooled analyses have reported improvements in pain and function, with several finding PRP compares favourably to hyaluronic acid injection and to placebo, particularly beyond the three-month mark. It is one of the better-supported uses of PRP anywhere in musculoskeletal medicine.
Important qualifications. Benefit is clearest in earlier-stage arthritis. In advanced, bone-on-bone disease, PRP is considerably less likely to help — it does not regrow cartilage, and no injection does. Patients with severe structural loss are usually better served by a surgical opinion, and we will say so rather than take your money.
PRP is not a replacement for loading. Quadriceps strength is one of the strongest predictors of function in knee arthritis. An injection that reduces pain enough to let you do meaningful rehabilitation is valuable; an injection instead of rehabilitation usually is not.
Corticosteroid works faster — often within days — but the effect typically fades within weeks to a few months, and repeated injections carry concerns about cartilage health over time. PRP works more slowly but the benefit tends to last longer, and it does not carry the same cartilage concerns. For a flare needing rapid relief, cortisone may still be the right tool.
Dr. Daniel Moghadam performs these injections himself. Accurate placement matters enormously with joint and tendon injections — product delivered into the wrong plane does nothing useful — and the assessment of whether PRP suits your problem at all is a clinical judgement rather than a checklist.
PRP's evidence base varies considerably by indication. Some uses are well supported by controlled trials; others are promising but thin. We will tell you which category yours falls into rather than presenting all applications as equally proven.
For most musculoskeletal problems, progressive loading and rehabilitation remain the foundation of treatment. PRP can support that process; it rarely replaces it. If you have not done structured rehabilitation, that is usually the first conversation.
PRP does not repair a complete tendon rupture, reverse advanced bone-on-bone arthritis, or fix mechanical instability. Where a surgical opinion is the honest recommendation, that is what you will hear.
Dr. Moghadam examines the joint, reviews any imaging you have, and determines whether PRP is genuinely likely to help your specific problem — or whether something else is the better answer.
A small volume of your blood is drawn, comparable to a routine laboratory test.
The sample is spun to concentrate the platelets and separate them from red blood cells. This takes ten to fifteen minutes.
The concentrate is injected into the target tissue. Local anesthetic is used, though not always inside the joint itself, since it can affect platelet function.
Relative rest for the first few days, then a graded return to activity. Improvement typically builds over four to twelve weeks.
The knee is the most-studied joint for PRP and the evidence is reasonably encouraging for mild to moderate osteoarthritis — multiple trials and pooled analyses report improvement in pain and function, with several finding it compares favourably to hyaluronic acid and placebo, particularly beyond three months. Benefit is much less reliable in advanced bone-on-bone disease.
No, and be cautious of anyone claiming otherwise. PRP does not regenerate lost cartilage. What it appears to do is modulate inflammation within the joint and improve the environment, which reduces pain and improves function. That is a worthwhile outcome, but it is not structural regrowth.
Cortisone works faster, often within days, but wears off within weeks to a few months and repeated injections raise concerns about cartilage over time. PRP works more slowly, typically over four to twelve weeks, but tends to last longer without the same concerns. For an acute flare needing quick relief, cortisone may still be appropriate.
It may delay it in earlier-stage arthritis, and that is a legitimate goal. It will not prevent replacement in advanced disease where the joint surface is largely gone. We will look at your imaging and examination and tell you honestly which situation you are in.
Relative rest for the first few days, avoiding impact and heavy loading. Most patients resume gentle activity within a week and build progressively from there. We would rather you return to structured strengthening than to unmodified running — quadriceps strength matters more for long-term function than the injection does.
Almost certainly, and this is important. Quadriceps strength is among the strongest predictors of function in knee arthritis. PRP that reduces pain enough to let you do meaningful rehabilitation is valuable. PRP as a substitute for rehabilitation generally is not.
For knee osteoarthritis a series of two or three injections spaced several weeks apart is common, though some patients do well with one. We reassess before recommending more rather than selling a course upfront.
Generally no — most insurers classify PRP as investigational for orthopedic use. We provide full pricing at your complimentary consultation.
Patients travel to our Beverly Hills office for knee pain treatment from across Los Angeles:
Our Beverly Hills office sits on Wilshire Blvd near the Beverly Hills–Los Angeles border, with on-site, valet, and street parking.
8907 Wilshire Blvd, Suite 270
Beverly Hills, CA 90211
Mon–Thu 10am–5pm
Fri 9am–5pm
Sat & Sun Closed
If your arthritis is mild to moderate, PRP is worth a conversation. If it is advanced, we will tell you that honestly.